Matsuoka Masao, Green Patrick L
Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.
Retrovirology. 2009 Aug 3;6:71. doi: 10.1186/1742-4690-6-71.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.
人类T细胞白血病病毒1型（HTLV-1）可引发成人T细胞白血病/淋巴瘤（ATL），还与多种淋巴细胞介导的疾病相关。HTLV-1碱性亮氨酸拉链（HBZ）基因在ATL中持续表达，最近成为了深入研究的对象。在本综述中，我们总结了关于HBZ的最新研究发现，并讨论了其不仅在病毒生命周期中，而且在HTLV-1疾病发病机制中的作用和功能。
