Zhao Tiejun
College of Chemistry and Life Sciences, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China.
Key Lab of Wildlife Biotechnology and Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China.
Viruses. 2016 Feb 2;8(2):34. doi: 10.3390/v8020034.
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense transcript of the HTLV-1 provirus. Among the HTLV-1-encoded viral genes, HBZ is the only gene that is constitutively expressed in all ATL cases. Recent studies have demonstrated that HBZ plays an essential role in oncogenesis by regulating viral transcription and modulating multiple host factors, as well as cellular signaling pathways, that contribute to the development and continued growth of cancer. In this article, I summarize the current knowledge of the oncogenic function of HBZ in cell proliferation, apoptosis, T-cell differentiation, immune escape, and HTLV-1 pathogenesis.
人类嗜T细胞病毒1型（HTLV-1）可引发成人T细胞白血病（ATL）和慢性炎症性疾病。HTLV-1碱性亮氨酸拉链因子（HBZ）作为HTLV-1前病毒的反义转录本进行转录。在HTLV-1编码的病毒基因中，HBZ是唯一在所有ATL病例中持续表达的基因。最近的研究表明，HBZ通过调节病毒转录、调控多种宿主因子以及细胞信号通路，在肿瘤发生过程中发挥着至关重要的作用，这些因子和通路有助于癌症的发展和持续生长。在本文中，我总结了目前关于HBZ在细胞增殖、凋亡、T细胞分化、免疫逃逸以及HTLV-1发病机制中的致癌功能的认识。
