过氧化物酶体增殖物激活受体γ C-2821T 与糖尿病对缺血性脑卒中风险的显著协同作用。
Significant synergistic effect of peroxisome proliferator-activated receptor gamma C-2821T and diabetes on the risk of ischemic stroke.
机构信息
School of Public Health, Taipei Medical University, Taipei, Taiwan.
出版信息
Diabetes Care. 2009 Nov;32(11):2033-5. doi: 10.2337/dc09-0717. Epub 2009 Aug 3.
Abstract
OBJECTIVE
To explore the relationship between the genetic polymorphisms of PPARgamma (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARgamma would modify the risk of ischemic stroke among patients with hypertension or diabetes.
RESEARCH DESIGN AND METHODS
The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARgamma were determined by PCR-restriction fragment-length polymorphism.
RESULTS
A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors.
CONCLUSIONS
The -2821C allele of PPARgamma was a strong predictor of ischemic stroke for diabetic patients.
摘要
目的
探讨过氧化物酶体增殖物激活受体γ（PPARγ）基因多态性（Pro12Ala、C1431T 和 C-2821T）与缺血性脑卒中风险的关系，并研究这些 PPARγ 基因多态性是否会改变高血压或糖尿病患者发生缺血性脑卒中的风险。
研究设计和方法
采用病例对照研究，纳入 537 例缺血性脑卒中患者和 537 例对照者。采用结构化问卷收集常规心血管危险因素和实验室结果等信息。采用聚合酶链反应-限制性片段长度多态性分析方法确定 PPARγ 基因多态性。
结果
-2821C 等位基因与糖尿病之间存在显著的交互作用，但与高血压之间无交互作用。与无这两种危险因素的患者相比，糖尿病合并-2821C 等位基因的患者发生缺血性脑卒中的风险显著升高（比值比 9.7）。
结论
PPARγ 的-2821C 等位基因是糖尿病患者发生缺血性脑卒中的一个强有力的预测因子。
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