[聚合酶链反应在轮状病毒分析中的应用。编码具有新型G血清型的人轮状病毒基本中和抗原VR7的基因的核苷酸序列]
[Use of the polymerase chain reaction for analysis of rotaviruses. Nucleotide sequence of a gene, coding for the basic neutralizing antigen VR7 of a human rotavirus with a new G-serotype].
作者信息
Bessarab I N, Novikova N A, Borodin A M
出版信息
Bioorg Khim. 1990 Dec;16(12):1689-92.
PMID:1965285
Abstract
A procedure based on polymerase chain reaction use for the detection of rotavirus has been developed. Full length cDNA copy of the VP7 gene coding for the major neutralization glycoprotein of the human rotavirus RK9 with an unusual "wide" electrophoretype is cloned and sequenced. Glycoprotein VP7 of RK9 has a unique amino acid composition in A and C antigenic regions. It shows that strain RK9 represents a new (12) rotavirus serotype.
摘要
已开发出一种基于聚合酶链反应的用于检测轮状病毒的方法。编码具有异常“宽”电泳型的人轮状病毒RK9主要中和糖蛋白的VP7基因的全长cDNA拷贝被克隆并测序。RK9的糖蛋白VP7在A和C抗原区域具有独特的氨基酸组成。这表明RK9毒株代表一种新的（12型）轮状病毒血清型。
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