Phillips T D, Clement B A, Kubena L F, Harvey R B
Department of Veterinary Public Health, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Vet Hum Toxicol. 1990;32 Suppl:15-9.
Our recent findings demonstrate that HSCAS can prevent aflatoxicosis in chickens and swine and significantly decreases the level of aflatoxin M1 residues in the milk of lactating dairy cattle. The basic mechanism for this action appears to involve sequestration of aflatoxin in the gastrointestinal tract and chemisorption (i.e., tight binding) to HSCAS which results in a reduction in aflatoxin bioavailability. Research is in progress to elucidate the specificity of HSCAS action and to construct a series of selective chemisorbents for mycotoxin control in livestock and poultry.
我们最近的研究结果表明，HSCAS可预防鸡和猪的黄曲霉毒素中毒，并显著降低泌乳奶牛牛奶中黄曲霉毒素M1残留水平。这种作用的基本机制似乎涉及在胃肠道中螯合黄曲霉毒素并与HSCAS进行化学吸附（即紧密结合），从而导致黄曲霉毒素生物利用度降低。目前正在进行研究以阐明HSCAS作用的特异性，并构建一系列用于控制畜禽霉菌毒素的选择性化学吸附剂。
