Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Biol Trace Elem Res. 2010 Jun;135(1-3):1-9. doi: 10.1007/s12011-009-8486-7. Epub 2009 Aug 5.
The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However, no properly confirmed tumor regression was reported so far in all probability because of neither theoretical nor experimental grounds for this proposal. The aim of the present review was to resume and discuss the material currently available on cesium salts and their applications in medicine. The presence of cesium in the cell does not guarantee high pH of its content, and there is no clinical evidence to support the claims that cancer cells are vulnerable to cesium. Cesium is relatively safe; signs of its mild toxicity are gastrointestinal distress, hypotension, syncope, numbness, or tingling of the lips. Nevertheless, total cesium intakes of 6 g/day have been found to produce severe hypokalemia, hypomagnesemia, prolonged QTc interval, episodes of polymorphic ventricular tachycardia, with or without torsade de pointes, and even acute heart arrest. However, full information on its acute and chronic toxicity is not sufficiently known. Health care providers should be aware of the cardiac complications, as a result of careless cesium usage as alternative medicine.
关于铯代谢和毒性的知识还很匮乏。基于所谓的“高 pH 值癌症疗法”假说，口服氯化铯已被广泛推广，这是一种补充替代医学癌症治疗方法。然而，到目前为止，由于没有理论和实验依据支持这一建议，还没有报告明确证实的肿瘤消退。本综述的目的是回顾和讨论目前关于铯盐及其在医学中的应用的资料。铯在细胞中的存在并不能保证其内容的高 pH 值，也没有临床证据支持癌细胞对铯敏感的说法。铯相对安全；其轻度毒性的迹象是胃肠道不适、低血压、晕厥、麻木或嘴唇刺痛。然而，每天摄入 6 克的总铯已被发现会导致严重的低钾血症、低镁血症、QTc 间期延长、多形性室性心动过速发作，伴有或不伴有尖端扭转型室性心动过速，甚至急性心脏骤停。然而，关于其急性和慢性毒性的完整信息还不够了解。医疗保健提供者应该意识到由于疏忽使用铯作为替代医学而导致的心脏并发症。
