Health Care Department, Universidad Autónoma Metropolitana-Xochimilco, 04960 Mexico City, Mexico.
Support Care Cancer. 2010 May;18(5):639-46. doi: 10.1007/s00520-009-0708-1. Epub 2009 Aug 6.
Knowledge of oral mucositis (OM) in patients with acute leukemia (AL) and chemotherapy (CT) has remained limited. Thus, a prospective, longitudinal study was undertaken to characterize clinical features, associated risk factors, and behavior of OM in a cohort of AL patients starting CT.
Prospective and longitudinal study. A cohort of patients, older than 15 years of age with AL, scheduled to receive CT, was followed from March 2006 to October 2007. At baseline and three times per week, for 21 days, patients had an oral examination performed using the Oral Mucositis Assessment Scale (OMAS); also, oral pain and difficulty to swallow were recorded using a visual analog scale. Weekly, salivary flow measurements (Schirmer's test modified version) were done.
A cohort of 29 AL patients was followed for a median time of 21 (range, 14-53) days; 12 (41.4%) developed OM, with a mean OMAS score of 0.181 (SD +/- 0.56) and a mean peak OMAS score of 1.8 (SD +/- 0.56). The OM onset mean time was 9.8 (range, 2-20, SD +/- 6.09) days, with a mean duration of 7 (range, 3-14, SD +/- 4.15) days. OM was significantly correlated with salivary flow [rs = 0.420 (P = 0.0051)], oral pain [rs = 0.47 (P < 0.0001)], ability to swallow [rs = 0.36 (P = 0.0001)], and type of food intake [rs = 0.38 (P < 0.0001)].
OM is a frequent and early side effect of CT closely correlated with oral pain, difficulty to swallow, and impairment in food intake.
急性白血病（AL）患者的口腔黏膜炎（OM）知识和化疗（CT）仍有限。因此，我们进行了一项前瞻性纵向研究，以描述开始 CT 的 AL 患者队列中 OM 的临床特征、相关危险因素和行为。
前瞻性和纵向研究。2006 年 3 月至 2007 年 10 月，我们对年龄大于 15 岁、计划接受 CT 的 AL 患者进行了队列研究。在基线和每周 3 次，共 21 天，使用口腔黏膜炎评估量表（OMAS）对患者进行口腔检查；还使用视觉模拟量表记录口腔疼痛和吞咽困难。每周进行唾液流率测量（改良 Schirmer 试验）。
29 例 AL 患者队列中位随访时间为 21 天（范围 14-53 天）；12 例（41.4%）发生 OM，OMAS 评分平均为 0.181（标准差 +/- 0.56），峰值 OMAS 评分平均为 1.8（标准差 +/- 0.56）。OM 发病平均时间为 9.8 天（范围 2-20 天，标准差 +/- 6.09），平均持续时间为 7 天（范围 3-14 天，标准差 +/- 4.15）。OM 与唾液流率显著相关（rs = 0.420，P = 0.0051），与口腔疼痛相关（rs = 0.47，P < 0.0001），与吞咽能力相关（rs = 0.36，P = 0.0001），与食物摄入类型相关（rs = 0.38，P < 0.0001）。
OM 是 CT 的一种常见且早期的副作用，与口腔疼痛、吞咽困难和进食障碍密切相关。
