J Neurol. 2009 Dec;256(12):2082-4. doi: 10.1007/s00415-009-5274-4.
To investigate differences in helper T cell immune responses in cerebrospinal fluid (CSF) between neuromyelitis optica (NMO) and multiple sclerosis (MS), we measured CSF levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-a and interferon-c at the time of relapse in 17 NMO patients and 21 MS patients using fluorescence-activated cell sorting. CSF IL-6 levels were significantly higher in NMO patients than in patients with MS (P = 0.001) and other neurological diseases (P = 0.001). The other cytokines tested were undetectable. Elevated CSF levels of IL-6 in only NMO supports the view of different pathophysiologies of NMO and MS. CSF IL-6 levels may be useful in the differential diagnosis of the two disorders.
为了研究视神经脊髓炎（NMO）和多发性硬化症（MS）患者脑脊液（CSF）中辅助性 T 细胞免疫应答的差异，我们通过流式细胞术，在 17 名 NMO 患者和 21 名 MS 患者复发时测量了 CSF 中白细胞介素（IL）-2、IL-4、IL-6、IL-10、肿瘤坏死因子-α和干扰素-c 的水平。NMO 患者的 CSF IL-6 水平明显高于 MS 患者（P = 0.001）和其他神经系统疾病患者（P = 0.001）。其他检测到的细胞因子均无法检测到。仅在 NMO 患者中升高的 CSF 水平 IL-6 支持 NMO 和 MS 的不同病理生理学观点。CSF IL-6 水平可能有助于两种疾病的鉴别诊断。
