地塞米松对重症急性胰腺炎大鼠多器官 P-选择素蛋白表达水平的影响。
Influence of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis.
机构信息
Department of General Surgery, Hangzhou First People's Hospital, Zhejiang, China.
出版信息
Inflamm Res. 2010 Jan;59(1):31-9. doi: 10.1007/s00011-009-0067-x. Epub 2009 Aug 5.
OBJECTIVE
To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP).
METHODS
Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed.
RESULTS
In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05).
CONCLUSIONS
Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
目的
研究地塞米松对重症急性胰腺炎（SAP）大鼠多器官 P-选择素蛋白表达水平的影响。
方法
将大鼠随机分为假手术组、模型对照组和地塞米松治疗组。在术后 3、6 和 12 h，观察每组三分之一大鼠的 P-选择素蛋白表达水平。
结果
在治疗组中，胰腺头部（6 h）、肺（12 h）、肝（3 h）和脾（6 和 12 h）中 P-选择素蛋白的表达水平明显低于模型对照组（P<0.05）。此外，治疗组肝（3 h）、肺（6 和 12 h）和脾（12 h）中 P-选择素蛋白染色强度和阳性率的产物也明显低于模型对照组（P<0.05）。
结论
地塞米松可抑制 SAP 大鼠多器官 P-选择素蛋白的表达。
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