Castellanos-Sánchez V O, Gómez-Conde E, Rocha-Gracia R C, Pimentel A, Aluja A, Hernández-Jáuregui P, Huerta M, Díaz-Orea M A
Laboratorio de Inmunología, Centro de Investigacion Biomedica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico.
J Parasitol. 2009 Dec;95(6):1287-94. doi: 10.1645/GE-2087.1.
Hormones play a significant role in murine Taenia crassiceps cysticercosis, and they may also participate in the susceptibility to Taenia solium cysticercosis. In the present study, in vitro effects are reported for human chorionic gonadotropin (hCG) on the larval stages of T. crassiceps (WFU strain) and T. solium. Our results reveal the presence of receptors for hCG in different developmental phases of both cultured parasites. On day 30, both taeniid species had the highest percentage of receptors in the neck, strobila, and suckers, but these receptors decreased by day 60, delimiting the segments and the exterior of the developing proglottids in T. solium. At the same time, there was a large number of hCG receptors in the area of the presumptive cirrus organ and in calcareous corpuscles within the parenchyma. This is the first report detecting receptors for hCG on different larval stages of T. crassiceps and T. solium. A direct effect of hCG could be recognized by the cysticerci as a factor contributing to the growth and development of T. crassiceps and T. solium cysticerci, respectively.
激素在小鼠粗颈带绦虫囊尾蚴病中起重要作用，它们也可能参与人体猪带绦虫囊尾蚴病的易感性。在本研究中，报告了人绒毛膜促性腺激素（hCG）对粗颈带绦虫（WFU株）和猪带绦虫幼虫阶段的体外作用。我们的结果显示，在两种培养寄生虫的不同发育阶段均存在hCG受体。在第30天，两种带绦虫在颈部、节片和吸盘处的受体百分比最高，但到第60天时这些受体减少，在猪带绦虫中界定了节片和发育中孕节的外部。同时，在推测的阴茎囊区域和实质内的石灰小体中有大量hCG受体。这是首次报道在粗颈带绦虫和猪带绦虫的不同幼虫阶段检测到hCG受体。hCG的直接作用可被囊尾蚴识别为分别促进粗颈带绦虫和猪带绦虫囊尾蚴生长发育的一个因素。
