Kalogeropoulos Gregory, Chang Shaun, Bolton Thomas, Jalbert Isabelle
School of Optometry and Vision Science, The University of New South Wales, Sydney, Australia.
Eye Contact Lens. 2009 Sep;35(5):255-9. doi: 10.1097/ICL.0b013e3181b4ec39.
To measure the effects of short-term high oxygen-transmissible (Dk) soft and rigid contact lens wear and eye rubbing on basal epithelial appearance and epithelial thickness.
Ten subjects were enrolled in a randomized crossover study. The subjects' left eye was used as a control, and the right eye either wore a high Dk soft lens, high Dk parallel fitted rigid gas-permeable lens, or was rubbed on 3 separate days. Epithelial basal cell regularity and central and peripheral epithelial thickness were assessed before and after 6-hr soft or rigid lens wear or 10-min rubbing using in vivo confocal microscopy and modified optical pachometry.
Basal cell regularity was unaffected by short-term lens wear or eye rubbing (Friedman Test, P=0.11 and 0.37 in test and control eyes, respectively). The peripheral epithelium was thicker than the central epithelium (repeated-measures analysis of variance, P=0.03) but remained unaffected by short-term lens wear or eye rubbing (repeated-measures analysis of variance, P>0.05, power <0.08).
Corneal epithelial thickness and basal cell morphology were not affected by short-term lens wear or eye rubbing in this pilot study.
测量短期佩戴高透氧性（Dk）软性和硬性隐形眼镜以及揉眼对角膜基底上皮外观和上皮厚度的影响。
10名受试者参与了一项随机交叉研究。受试者的左眼作为对照，右眼在3个不同日期分别佩戴高Dk软性隐形眼镜、高Dk平行配适硬性透气性隐形眼镜或进行揉眼操作。在佩戴软性或硬性隐形眼镜6小时或揉眼10分钟前后，使用共聚焦显微镜和改良光学厚度测量法评估角膜基底细胞规则性以及中央和周边上皮厚度。
短期佩戴隐形眼镜或揉眼对基底细胞规则性无影响（Friedman检验，试验眼和对照眼中P值分别为0.11和0.37）。周边上皮比中央上皮厚（重复测量方差分析，P = 0.03），但短期佩戴隐形眼镜或揉眼对其无影响（重复测量方差分析，P>0.05，效能<0.08）。
在这项初步研究中，短期佩戴隐形眼镜或揉眼对角膜上皮厚度和基底细胞形态无影响。
