在患有眼部过敏的受试者中，测量了五个位置因揉眼引起的眼压和角膜厚度变化。
Eye rubbing-induced changes in intraocular pressure and corneal thickness measured at five locations, in subjects with ocular allergy.
作者信息
Osuagwu Uchechukwu L, Alanazi Saud A
机构信息
Visual and Ophthalmic Optics Group (Chronic Disease&Ageing Domain), Institute of Health&Biomedical Innovation, School of Optometry&Vision Sciences, Queensland University of Technology, Kelvin Grove, Brisbane 4059, Australia.
Department of Optometry & Vision Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Saudi Arabia.
出版信息
Int J Ophthalmol. 2015 Feb 18;8(1):81-8. doi: 10.3980/j.issn.2222-3959.2015.01.15. eCollection 2015.
AIM
To assess the effects of eye rubbing on corneal thickness (CT) and intraocular pressure (IOP) measurements obtained 0-30min after habitual eye rubbing in symptomatic patients.
METHODS
Measurements of IOP and CT were obtained at five locations (central, temporal, superior, nasal and inferior) before, and every 5min for 30min interval after 30s of eye rubbing, for 25 randomly selected eyes of 14 subjects with ocular allergy and 11 age-matched normals. Differences in measurements were calculated in each group [Baseline measurements minus measurements recorded at each time interval after eye rubbing (for IOP), and for each corneal location (for CT)] and comparison were then made between groups (allergic versus control) for differences in any observed effects.
RESULTS
Within groups, baseline mean IOPs in the allergic patient-group (14.2±3.0 mm Hg) and in the control group (13.1±1.9 mm Hg) were similar at all times, after eye rubbing (P >0.05, for all). The maximum reduction in IOP was 0.8 mm Hg in the control subjects and the maximum increase was also 0.8 mm Hg in the allergic subjects. Between groups (allergic versus control), the changes in IOP remained under 1 mm Hg at all times (P=0.2) after 30min of eye rubbing. Between 0 and 30min of CT measurements after eye rubbing, the mean central CT (CCT), inferior CT (ICT), superior CT (SCT), temporal CT (TCT) and nasal CT (NCT) did not vary significantly from baseline values in the control and allergic-subject groups (P>0.05, for both). Between both groups, changes in CT were similar at all locations (P>0.05) except for the TC which was minimally thinner by about 4.4 µm (P=0.001) in the allergic subjects than in the control subjects, 30min following 30s of eye rubbing.
CONCLUSION
IOP measured in allergic subjects after 30s of habitual eye rubbing was comparable with that obtained in normal subjects at all times between 0 and 30min. Although, CT in the allergic subjects were similar to those of the control subjects at all times, it varied between +10 and -7.5 µm following eye rubbing, with the temporal cornea showing consistent reductions in thickness in the subjects with allergy. However, this reduction was minimal and was considered to not be clinically relevant.
目的
评估有症状患者习惯性揉眼后0至30分钟内揉眼对角膜厚度（CT）和眼压（IOP）测量值的影响。
方法
对14名眼部过敏患者和11名年龄匹配的正常人的25只随机选取的眼睛，在揉眼30秒之前以及之后每隔5分钟测量一次眼压和角膜厚度，共测量30分钟，测量位置包括五个部位（中央、颞侧、上方、鼻侧和下方）。计算每组测量值的差异[基线测量值减去揉眼后每个时间间隔记录的测量值（眼压），以及每个角膜位置的测量值（角膜厚度）]，然后比较两组（过敏组与对照组）观察到的任何效应的差异。
结果
在组内，过敏患者组（14.2±3.0毫米汞柱）和对照组（13.1±1.9毫米汞柱）的基线平均眼压在揉眼后的所有时间点均相似（所有P>0.05）。对照组眼压最大降低值为0.8毫米汞柱，过敏组眼压最大升高值也为0.8毫米汞柱。在组间（过敏组与对照组），揉眼30分钟后眼压变化在所有时间点均保持在1毫米汞柱以内（P = 0.2）。在揉眼后的角膜厚度测量的0至30分钟内，对照组和过敏组的中央角膜厚度（CCT）、下方角膜厚度（ICT）、上方角膜厚度（SCT）、颞侧角膜厚度（TCT）和鼻侧角膜厚度（NCT）与基线值相比均无显著变化（两组均P>0.05）。在两组之间，除了揉眼30秒后30分钟时过敏组的颞侧角膜厚度比对照组略微薄约4.4微米（P = 0.001）外，所有位置的角膜厚度变化均相似（P>0.05）。
结论
习惯性揉眼30秒后，过敏受试者测量的眼压在0至30分钟内的所有时间点均与正常受试者的眼压相当。尽管过敏受试者的角膜厚度在所有时间点均与对照组相似，但揉眼后角膜厚度在+10至 -7.5微米之间变化，过敏受试者的颞侧角膜厚度持续降低。然而，这种降低幅度极小，被认为无临床相关性。
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