Boone Adrienne, Hui Alex, Jones Lyndon
Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada.
Eye Contact Lens. 2009 Sep;35(5):260-7. doi: 10.1097/ICL.0b013e3181b26c49.
To investigate the uptake and release kinetics of the synthetic glucocorticoid anti-inflammatory drug dexamethasone into various conventional and silicone hydrogel contact lens materials.
Three conventional and six silicone hydrogel lenses were used in this study. A 0.1% dexamethasone solution was formulated and used to dope the various contact lens materials. The uptake and release of the drug was measured using a UV-visible light spectrophotometer at various time points during a period of 24 hr for each phase.
Statistical analysis showed that all lenses took up a significant amount of dexamethasone. Alphafilcon A and lotrafilcon A showed the greatest uptake of dexamethasone, at 118 +/- 10 microg/lens and 102 +/- 11 microg/lens, respectively, and galyfilcon took up the least amount of drug at 34 +/- 6 microg/lens. The release of the drug from the lens materials was also statistically significant. The majority of the lenses released between 20 and 30 microg/lens, except for alphafilcon A and lotrafilcon A, which released a statistically different amount of drug when compared with the other lens materials. Alphafilcon A released 65 +/- 1.3 microg/lens, whereas lotrafilcon A slowly released only 11 +/- 0.2 microg/lens.
Although most of the lenses released enough drug to have anti-inflammatory action, none of the materials released drug for a long enough period of time to be clinically useful as a drug delivery device.
研究合成糖皮质激素抗炎药物地塞米松在各种传统和硅水凝胶隐形眼镜材料中的摄取和释放动力学。
本研究使用了三种传统隐形眼镜和六种硅水凝胶镜片。配制了0.1%的地塞米松溶液，并用于掺杂各种隐形眼镜材料。在每个阶段的24小时内，于不同时间点使用紫外可见分光光度计测量药物的摄取和释放情况。
统计分析表明，所有镜片都摄取了大量地塞米松。Alphafilcon A和lotrafilcon A摄取的地塞米松量最大，分别为118±10微克/镜片和102±11微克/镜片，而galyfilcon摄取的药物量最少，为34±6微克/镜片。药物从镜片材料中的释放也具有统计学意义。除Alphafilcon A和lotrafilcon A外，大多数镜片释放的药物量在20至30微克/镜片之间，与其他镜片材料相比，Alphafilcon A和lotrafilcon A释放的药物量在统计学上有差异。Alphafilcon A释放了65±1.3微克/镜片，而lotrafilcon A仅缓慢释放了11±0.2微克/镜片。
尽管大多数镜片释放的药物足以产生抗炎作用，但没有一种材料释放药物的时间足够长，以至于在临床上作为药物递送装置有用。
