Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Eye Department, J. Strus City Hospital, Szwajcarska 3, 61-285 Poznań, Poland.
Molecules. 2021 Sep 14;26(18):5577. doi: 10.3390/molecules26185577.
This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.
本文综述了隐形眼镜作为一种创新药物传递系统在眼部疾病治疗中的作用。目前的眼科药物传递系统并不完善，尤其是眼药水，其中约 95%的有效物质会通过泪液排出而损失。根据文献，许多跨学科研究已经着眼于隐形眼镜增加局部治疗药物渗透的能力。隐形眼镜通过将药物释放到隐形眼镜两侧的两层泪液中，限制药物损失，最终延长与眼表面的接触时间。得益于重量型软性隐形眼镜，可以实现药物的持续释放和长时间释放。本文综述了通过隐形眼镜给药的各种技术，探讨了它们的优缺点。此外，还广泛研究了基于隐形眼镜的药物传递系统的潜力。
