Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
J Hum Hypertens. 2010 May;24(5):312-9. doi: 10.1038/jhh.2009.65. Epub 2009 Aug 6.
We tested whether lowering of blood pressure (BP) on the dietary approaches to stop hypertension (DASH) diet was associated with changes in peripheral vascular function: endothelial function, assessed by flow-mediated vasodilatation (FMD) of the brachial artery, and subcutaneous adipose tissue blood flow (ATBF). We also assessed effects on heart rate variability (HRV) as a measure of autonomic control of the heart. We allocated 27 men and women to DASH diet and control groups. We measured FMD, ATBF and HRV on fasting and after ingestion of 75 g glucose, before and after 30 days on dietary intervention, aiming for weight maintenance. The control group did not change their diet. The DASH-diet group complied with the diet as shown by significant reductions in systolic (P<0.001) and diastolic (P=0.005) BP, and in plasma C-reactive protein (P<0.01), LDL-cholesterol (P<0.01) and apolipoprotein B (P=0.001), a novel finding. Body weight changed by <1 kg. There were no changes in the control group. We found no changes in FMD, or in ATBF, in the DASH-diet group, although heart rate fell (P<0.05). Glucose and insulin concentrations did not change. In this small-scale study, the DASH diet lowered BP independently of peripheral mechanisms.
我们测试了降低血压（BP）对饮食方法阻止高血压（DASH）饮食是否与外周血管功能的变化有关：肱动脉血流介导的舒张功能（FMD）评估的内皮功能，和皮下脂肪组织血流（ATBF）。我们还评估了心率变异性（HRV）作为心脏自主控制的衡量标准的影响。我们将 27 名男性和女性分配到 DASH 饮食组和对照组。我们在空腹和摄入 75 克葡萄糖后测量 FMD、ATBF 和 HRV，然后在 30 天的饮食干预前后进行测量，目的是保持体重。对照组没有改变他们的饮食。DASH 饮食组遵守饮食，收缩压（P<0.001）和舒张压（P=0.005）显著降低，血浆 C 反应蛋白（P<0.01）、低密度脂蛋白胆固醇（P<0.01）和载脂蛋白 B（P=0.001）也显著降低，这是一个新发现。体重变化小于 1 公斤。对照组没有变化。我们发现 DASH 饮食组的 FMD 或 ATBF 没有变化，尽管心率下降（P<0.05）。葡萄糖和胰岛素浓度没有变化。在这项小规模研究中，DASH 饮食独立于外周机制降低了血压。
