Beer M, Stäb D, Oechsner M, Hahn D, Köstler H, Hebestreit H, Jakob P
Institut für Röntgendiagnostik, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg.
Radiologe. 2009 Aug;49(8):732-8. doi: 10.1007/s00117-009-1883-2.
Current diagnostic tools for the assessment of lung function are limited by global measurements or the need for radioactive tracers. Ideally, these tools should allow quantitative, regional distinct analyses without exposure to radiation. The current paper presents oxygen-enhanced functional MRI for assessment of lung ventilation. First applied in humans in 1996, a considerable amount of experience is now available on 1.5T scanners. The generation of quantitative T1-maps shows a high clinical potential. Low-field MR scanners, which are mostly open-designed, are especially interesting for functional lung imaging. The open design has advantages in respect to patient comfort by lower noise production and easy access to the patients and the costs are lower (no need for helium cooling). Lower signal-to-noise ratios can be overcome by changing the relaxation times. New navigator techniques allow further compensations. This article focuses on the presentation of low-field scanners and the application of T1 and T2(*) maps is described for healthy volunteers and first patients.
目前用于评估肺功能的诊断工具受到整体测量或对放射性示踪剂需求的限制。理想情况下，这些工具应能在不接触辐射的情况下进行定量的区域差异分析。本文介绍了用于评估肺通气的氧增强功能磁共振成像。1996年首次应用于人体，目前在1.5T扫描仪上已有大量经验。定量T1图的生成显示出很高的临床潜力。大多为开放式设计的低场磁共振扫描仪对功能性肺部成像尤其有吸引力。开放式设计在患者舒适度方面具有优势，因为噪音产生较低，便于接近患者，而且成本较低（无需氦冷却）。通过改变弛豫时间可以克服较低的信噪比。新的导航技术允许进一步补偿。本文重点介绍低场扫描仪，并描述了T1和T2（*）图在健康志愿者和首批患者中的应用。
