Pracht Eberhard D, Arnold Johannes F T, Wang Tungte, Jakob Peter M
Department of Experimental Physics 5, University of Würzburg, Germany.
Magn Reson Med. 2005 May;53(5):1193-6. doi: 10.1002/mrm.20448.
Magnetic susceptibility gradients caused by tissue/air interfaces lead to very short T(2)* times in the human lung. These susceptibility gradients are dependent on the magnetic susceptibility of the respiratory gas and therefore should influence T(2)* relaxation. In this work, a technique for quantitative T(2)* mapping of the human lung during one breath hold is presented. Using this method, the lung T(2)* relaxation time was measured under normoxic (room air, 21% O(2)) and hyperoxic (100% O(2)) conditions to verify this assumption. The mean T(2)* difference between room air and 100% O(2) is about 10% and contains ventilation information, since only ventilated regions contribute to signal change due to different susceptibility gradients.
由组织/空气界面引起的磁化率梯度导致人类肺部的T(2)*时间非常短。这些磁化率梯度取决于呼吸气体的磁化率，因此应该会影响T(2)*弛豫。在这项工作中，提出了一种在一次屏气期间对人类肺部进行定量T(2)*成像的技术。使用该方法，在常氧（室内空气，21% O(2)）和高氧（100% O(2)）条件下测量肺部T(2)*弛豫时间，以验证这一假设。室内空气和100% O(2)之间的平均T(2)*差异约为10%，并且包含通气信息，因为由于不同的磁化率梯度，只有通气区域会导致信号变化。
