Department of Medical Imaging, Jinling Hospital, Clinical School of Medical College, Nanjing University, Xuanwu District, Nanjing, Jiangsu Province, China.
Eur Radiol. 2009 Dec;19(12):2844-54. doi: 10.1007/s00330-009-1518-z.
The purpose of the study was to compare the ability of dual energy CT (DECT) and perfusion scintigraphy (PS) to detect pulmonary embolism (PE) in a rabbit model. Gelfoam (n = 20) or saline (n = 4) was injected into the femoral vein of rabbits. After 2 h, DECT pulmonary angiography (CTPA) was used to create blood flow imaging (BFI) and fusion images. The rabbits then underwent PS. Pathological determination of locations and numbers of lung lobes with PE was recorded. The sensitivity and specificity for BFI, CTPA, fused images and PS were calculated using the pathological results as reference standards. Compared with pathological evaluation, CTPA correctly identified PE in 40 lobes and absence of emboli in 80 lobes, corresponding to a sensitivity and specificity of 100%. BFI and fused images correctly identified PE in 40 lobes and the absence of emboli in 78 lobes, corresponding to a sensitivity and specificity of 100% and 98%, respectively. PS correctly detected 27 lobes with PE and 65 lobes without PE, corresponding to a sensitivity and specificity of 68% and 81%, respectively. BFI, CTPA and fused images derived from a single contrast-enhanced DECT provide a higher diagnostic accuracy of detecting PE than PS in a rabbit model.
本研究旨在比较双能 CT（DECT）和灌注闪烁显像（PS）在兔模型中检测肺栓塞（PE）的能力。明胶海绵（n = 20）或生理盐水（n = 4）注入兔股静脉。2 小时后，行 DECT 肺动脉造影（CTPA）以创建血流成像（BFI）和融合图像。然后对兔子进行 PS。记录存在 PE 的肺叶的位置和数量的病理确定。使用病理结果作为参考标准，计算 BFI、CTPA、融合图像和 PS 的敏感性和特异性。与病理评估相比，CTPA 正确识别 40 个肺叶中的 PE 和 80 个肺叶中的无栓塞，敏感性和特异性均为 100%。BFI 和融合图像正确识别 40 个肺叶中的 PE 和 78 个肺叶中的无栓塞，敏感性和特异性分别为 100%和 98%。PS 正确检测到 27 个存在 PE 的肺叶和 65 个无 PE 的肺叶，敏感性和特异性分别为 68%和 81%。源自单次对比增强 DECT 的 BFI、CTPA 和融合图像提供了比 PS 在兔模型中检测 PE 的更高的诊断准确性。
