Pavelić Jasminka, Zeljko Zarko
Institut Ruder Bośković, Zavod za molekularnu medicinu, Laboratorij za molekularnu onkologiju.
Lijec Vjesn. 2002 Jun-Jul;124(6-7):211-9.
Human prostate gland is a composite organ made up of several glandular and nonglandular components. There are three distinct glandular regions. These are the peripheral, the central, and the transition zone. They differ histologically and biologically. The central zone is relatively resistant to carcinoma and other diseases. The peripheral zone is the site of origin of most carcinomas and prostatic intraepithelial neoplasia (PIN). Most authors now agree that PIN is a likely precursor of at least a proportion of carcinomas arising in this zone. The transition zone is the exclusive site of origin of benign prostatic hyperplasia (BPH). A subset of prostate cancers arises in this zone as well. Most are found incidentally at transuretral resection (TUR). A morphological lesion, atypical adenomatous hyperplasia (AH), arising also in transition zone, provides a possible link between BPH and transition zone cancers. However, further studies of biological markers of neoplastic transformation are needed to address this issue.
人类前列腺是一个由多个腺性和非腺性成分组成的复合器官。有三个不同的腺性区域。分别是外周区、中央区和移行区。它们在组织学和生物学上存在差异。中央区对癌症和其他疾病相对具有抵抗力。外周区是大多数癌症和前列腺上皮内瘤变（PIN）的起源部位。现在大多数作者都认为，PIN至少是该区域一部分癌症的可能前体。移行区是良性前列腺增生（BPH）的唯一起源部位。也有一部分前列腺癌起源于该区域。大多数是在经尿道前列腺切除术（TUR）时偶然发现的。同样出现在移行区的一种形态学病变，非典型腺瘤样增生（AH），为BPH和移行区癌症之间提供了可能的联系。然而，需要进一步研究肿瘤转化的生物学标志物来解决这个问题。
