Department of Psychology, Washington State University, PO Box 644820, Pullman, WA, 99164-4820, USA.
UCLA Center for Cannabis and Cannabinoids, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, Department of Anesthesiology and Perioperative Medicine, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Sci Rep. 2024 Jul 13;14(1):16163. doi: 10.1038/s41598-024-66879-0.
Cannabigerol (CBG) is a phytocannabinoid increasing in popularity, with preclinical research indicating it has anxiolytic and antidepressant effects. However, there are no published clinical trials to corroborate these findings in humans. The primary objective of this study was to examine acute effects of CBG on anxiety, stress, and mood. Secondary objectives were to examine whether CBG produces subjective drug effects or motor and cognitive impairments. A double-blind, placebo-controlled cross-over field trial was conducted with 34 healthy adult participants. Participants completed two sessions (with a one-week washout period) via Zoom. In each, they provided ratings of anxiety, stress, mood, and subjective drug effects prior to double-blind administration of 20 mg hemp-derived CBG or placebo tincture (T0). These ratings were collected again after participants ingested the product and completed an online survey (T1), the Trier Social Stress Test (T2), a verbal memory test and the DRUID impairment app (T3). Relative to placebo, there was a significant main effect of CBG on overall reductions in anxiety as well as reductions in stress at T1. CBG also enhanced verbal memory relative to placebo. There was no evidence of subjective drug effects or impairment. CBG may represent a novel option to reduce stress and anxiety in healthy adults.
大麻二醇（CBG）是一种日益流行的植物大麻素，临床前研究表明它具有抗焦虑和抗抑郁作用。然而，目前还没有发表的临床试验来证实这些在人类身上的发现。本研究的主要目的是研究 CBG 对焦虑、压力和情绪的急性影响。次要目标是研究 CBG 是否会产生主观药物效应或运动和认知障碍。一项双盲、安慰剂对照的交叉现场试验在 34 名健康成年参与者中进行。参与者通过 Zoom 完成了两次会议（间隔一周的清洗期）。在每次会议中，他们在双盲给予 20 毫克大麻素或安慰剂 tincture（T0）之前，对焦虑、压力、情绪和主观药物效应进行了评分。在参与者服用产品并完成在线调查（T1）、特里尔社会压力测试（T2）、言语记忆测试和 DRUID 障碍应用程序（T3）后，再次对这些评分进行了收集。与安慰剂相比，CBG 对 T1 时的总体焦虑减轻以及压力减轻有显著的主要影响。CBG 也相对于安慰剂增强了言语记忆。没有证据表明存在主观药物效应或障碍。CBG 可能是一种减轻健康成年人压力和焦虑的新选择。
