Lin Wan-Lung, Lin Wen-Chi, Chang Ya-Ching, Yang Li-Cheng, Hung Shuen-Iu, Hong Hong-Shang, Chung Wen-Hung
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Am J Clin Dermatol. 2009;10(5):339-42. doi: 10.2165/11310610-000000000-00000.
Intravenous immunoglobulin (IVIG) has emerged as a promising treatment that interrupts the progression of Stevens-Johnson syndrome (SJS). Our patient experienced an uncommon adverse effect, non-eczematous, vesiculobullous eruptions, after treatment with IVIG. These new lesions developed rapidly on the palms while most previous SJS bullous lesions subsided. A skin biopsy of these new lesions showed an intracorneal vesicle, without epidermal necrosis, with inflammatory cell infiltration. IVIG-induced, vesiculobullous eruptions are discussed, along with their possible pathogenesis. With the increasing use of IVIG for treatment of bullous dermatoses, recognition of this rare adverse effect is important for prompt differential diagnosis.
静脉注射免疫球蛋白（IVIG）已成为一种有前景的治疗方法，可中断史蒂文斯-约翰逊综合征（SJS）的进展。我们的患者在接受IVIG治疗后出现了一种罕见的不良反应，即非湿疹性水疱大疱性皮疹。这些新皮疹在手掌上迅速出现，而之前大多数SJS大疱性皮疹消退。对这些新皮疹进行皮肤活检显示为角膜内水疱，无表皮坏死，伴有炎症细胞浸润。本文讨论了IVIG诱导的水疱大疱性皮疹及其可能的发病机制。随着IVIG在大疱性皮肤病治疗中的应用日益增加，认识到这种罕见的不良反应对于及时进行鉴别诊断很重要。
