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1例川崎病表现为非典型皮肤受累并酷似史蒂文斯-约翰逊综合征。

A case of Kawasaki disease presenting with atypical cutaneous involvement and mimicking Stevens-Johnson syndrome.

作者信息

Demir Ferhat, Abul Mehtap Haktanir, Dilber Embiya, Orhan Fazil, Kalyoncu Mukaddes

机构信息

Department of Pediatric Rheumatology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

Department of Pediatric Allergy and Immunology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

出版信息

North Clin Istanb. 2018 Dec 10;7(1):67-70. doi: 10.14744/nci.2018.84748. eCollection 2020.

DOI:10.14744/nci.2018.84748
PMID:32232207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7103744/
Abstract

Kawasaki disease is the second most common cause of childhood vasculitis. Cutaneous manifestation, which is the diagnostic criteria of Kawasaki disease, may show atypical course and causes conflict in diagnosis for physicians. A 14-month-old girl treated with intravenous immunoglobulin after diagnosed with KD. Target lesions and a vesicular rash developed on the whole body during the course of the disease. Methylprednisolone was added to the treatment. All atypical skin lesions and disease findings were improved using IVIG and subsequent methylprednisolone therapy. Cutaneous signs of KD may show atypical course. Thus, it may lead to confusion in diagnosis with Stevens-Johnson syndrome.

摘要

川崎病是儿童血管炎的第二大常见病因。皮肤表现作为川崎病的诊断标准，可能呈现非典型病程，给医生的诊断带来困扰。一名14个月大的女童在被诊断为川崎病后接受了静脉注射免疫球蛋白治疗。病程中全身出现了靶形皮损和水疱性皮疹。治疗中加用了甲泼尼龙。使用静脉注射免疫球蛋白及随后的甲泼尼龙治疗后，所有非典型皮肤病变和疾病表现均得到改善。川崎病的皮肤体征可能呈现非典型病程。因此，可能导致与史蒂文斯－约翰逊综合征的诊断混淆。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/7103744/ab87e712a591/NCI-7-67-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/7103744/bcc986371bc0/NCI-7-67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/7103744/ab87e712a591/NCI-7-67-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/7103744/bcc986371bc0/NCI-7-67-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da45/7103744/ab87e712a591/NCI-7-67-g002.jpg

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本文引用的文献

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Significant dermatological side effects of intravenous immunoglobulin.静脉注射免疫球蛋白的显著皮肤副作用。
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