Kim M-Y, Kim K-S, McConnell F, Lane P
Department of Bioinformatics and Life Science, The College of Natural Science, Soongsil University, Seoul, Korea.
Clin Exp Immunol. 2009 Jul;157(1):20-6. doi: 10.1111/j.1365-2249.2009.03932.x. Epub 2009 Mar 18.
In this review, we summarize the current understanding of the multiple functions of the mouse lymphoid tissue inducer (LTi) cells in: (i) the development of organized lymphoid tissue, (ii) the generation and maintenance of CD4-dependent immunity in adult lymphoid tissues; and (iii) the regulation of central tolerance in thymus. By contrast with mouse LTi cells, which have been well described, the human equivalent is only just beginning to be characterized. Human LTi-like cells expressing interleukin (IL)-22 have been identified recently and found to differentiate into natural killer (NK) cells. The relationship of LTi cells to NK cells is discussed in the light of several studies reporting a close relationship in the mouse between LTi cells and transcription factor retinoid-related orphan receptor gammat-dependent IL-22 producing NK cells in the gut. We also outline our data suggesting that these cells are present in adult human lymphoid tissues.
在本综述中，我们总结了目前对小鼠淋巴组织诱导细胞（LTi细胞）多种功能的理解，这些功能包括：（i）有组织的淋巴组织的发育；（ii）成年淋巴组织中CD4依赖性免疫的产生和维持；以及（iii）胸腺中中枢耐受的调节。与已被充分描述的小鼠LTi细胞相比，人类的等效细胞才刚刚开始被表征。最近已鉴定出表达白细胞介素（IL）-22的人类LTi样细胞，并发现它们可分化为自然杀伤（NK）细胞。鉴于多项研究报道了小鼠肠道中LTi细胞与转录因子视黄酸相关孤儿受体γt依赖性产生IL-22的NK细胞之间的密切关系，我们讨论了LTi细胞与NK细胞的关系。我们还概述了我们的数据，表明这些细胞存在于成年人类淋巴组织中。
