Gosau Martin, Vogel Corinna, Moralis Antonios, Proff Peter, Kleinheinz Johannes, Driemel Oliver
Department of Cranio-Maxillo-Facial Surgery, University of Regensburg, Regensburg, Germany.
Head Face Med. 2009 Aug 6;5:16. doi: 10.1186/1746-160X-5-16.
A 22-year-old man presented for orthodontic surgery because of mandibular prognathism. Clinical symptoms suggested acromegaly, and diagnosis was verified by an endocrinologist as well as by radiograph. Bilateral mandibular prognathism often represents the first and most striking physical characteristic of acromegaly; usually, it is also the main reason why patients seek help from orthodontists or maxillo-facial surgeons. This case report recapitulates the clinical and histopathological findings in pituitary growth hormone (GH) adenomas and emphasises their importance in surgical orthodontic planning. Mandibular prognatism, macroglossia and abnormal growth of hands and feet represent strong indicators for the diagnosis of acromegaly. This disease and its complications not only affect the entire body but increase mortality if the pituitary gland tumour remains untreated.
一名22岁男性因下颌前突前来接受正畸手术。临床症状提示肢端肥大症，内分泌科医生及影像学检查均证实了该诊断。双侧下颌前突通常是肢端肥大症的首要且最显著的体征；通常，这也是患者寻求正畸医生或颌面外科医生帮助的主要原因。本病例报告总结了垂体生长激素（GH）腺瘤的临床和组织病理学发现，并强调了它们在正畸手术规划中的重要性。下颌前突、巨舌症以及手脚异常生长是肢端肥大症诊断的有力指标。这种疾病及其并发症不仅会影响全身，而且如果垂体肿瘤不治疗，会增加死亡率。
