Truong Anh P, Aubele Danielle L, Probst Gary D, Neitzel Martin L, Semko Chris M, Bowers Simeon, Dressen Darren, Hom Roy K, Konradi Andrei W, Sham Hing L, Garofalo Albert W, Keim Pamela S, Wu Jing, Dappen Michael S, Wong Karina, Goldbach Erich, Quinn Kevin P, Sauer John-Michael, Brigham Elizabeth F, Wallace William, Nguyen Lan, Hemphill Susanna S, Bova Michael P, Bard Frédérique, Yednock Ted A, Basi Guriqbal
Department of Medicinal Chemistry, Elan Pharmaceuticals, 800 Gateway Boulevard, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett. 2009 Sep 1;19(17):4920-3. doi: 10.1016/j.bmcl.2009.07.092. Epub 2009 Jul 23.
In this Letter, we report our strategy to design potent and metabolically stable gamma-secretase inhibitors that are efficacious in reducing the cortical Abetax-40 levels in FVB mice via a single PO dose.
在本信函中，我们报告了我们设计强效且代谢稳定的γ-分泌酶抑制剂的策略，这些抑制剂通过单次口服给药能有效降低FVB小鼠皮质中Aβ40的水平。
