Sheng Jian-qiu, Li Shi-rong, Wu Zi-tao, Xia Chang-hong, Wu Xia, Chen Jigui, Rao Jianyu
Department of Gastroenterology, Beijing Military General Hospital, Dongcheng District, Beijing, China.
Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2182-5. doi: 10.1158/1055-9965.EPI-09-0309.
Recent proteomic studies identified Transferrin (Tf) as a potential biomarker for cancer. We examined the efficacy of the newly developed Tf dipstick for detecting colorectal cancer and premalignant lesions, and compared that to Immuno Fecal Occult Blood test (IFOBT). Fecal samples from 110 patients including 40 colorectal cancer, 36 premalignant subjects (including 16 with high-risk adenomas and 20 with ulcerative colitis), and 34 low-risk subjects were collected before colonoscopic examination. Compared with IFOBT, Tf had a significantly higher positive rate in patients with colorectal cancer and premalignant lesions (76% for Tf versus 61% for IFOBT, respectively; chi(2) = 4.38; P < 0.05). The difference of positivity was mainly observed in patients with premalignant lesions (72% for Tf versus 44% for IFOBT; chi(2) = 5.71; P < 0.05), whereas the positive rates in cancer group and in low-risk group were similar (both P > 0.05). Combining Tf with IFOBT together (either/or) had 90% positive rate in cancer patients, 78% in premalignant patients, and 29% in low-risk subjects. The overall accuracy of IFOBT and Tf tests for detecting colorectal cancer and premalignant lesion was 69.0% and 76.4%, respectively. Tf dipstick test seems to be a highly sensitive test for detecting not only cancer, but also premalignant lesions, and provides an additional tool for colorectal cancer screening.
近期的蛋白质组学研究确定转铁蛋白（Tf）为一种潜在的癌症生物标志物。我们检测了新开发的Tf试纸条检测结直肠癌及癌前病变的效果，并将其与免疫粪便潜血试验（IFOBT）进行比较。在结肠镜检查前，收集了110例患者的粪便样本，其中包括40例结直肠癌患者、36例癌前病变患者（包括16例高危腺瘤患者和20例溃疡性结肠炎患者）以及34例低风险受试者。与IFOBT相比，Tf在结直肠癌和癌前病变患者中的阳性率显著更高（Tf分别为76%，IFOBT为61%；χ² = 4.38；P < 0.05）。阳性差异主要在癌前病变患者中观察到（Tf为72%，IFOBT为44%；χ² = 5.71；P < 0.05），而癌症组和低风险组的阳性率相似（均P > 0.05）。将Tf与IFOBT联合使用（二者选一），癌症患者的阳性率为90%，癌前病变患者为78%，低风险受试者为百分之29%。IFOBT和Tf检测结直肠癌和癌前病变的总体准确率分别为69.0%和76.4%。Tf试纸条检测似乎不仅对检测癌症，而且对检测癌前病变都是一种高度敏感的检测方法，并为结直肠癌筛查提供了一种额外的工具。
