Central Laboratory, Yanbian University Hospital & Key Laboratory of Pathobiology, Yanbian University, State Ethnic Affairs Commission, Yanbian University, Yanji, China.
Department of Pathology & Cancer Research Center, Yanbian University, Yanji, China.
Front Immunol. 2024 Sep 18;15:1462505. doi: 10.3389/fimmu.2024.1462505. eCollection 2024.
Ferroptosis is a new form of cell death that differs from traditional forms of death. It is ferroptosis-dependent lipid peroxidation death. Colorectal cancer(CRC) is the most common tumor in the gastrointestinal tract with a long occultation period and a poor five-year prognosis. Exploring effective systemic treatments for CRC remains a great challenge worldwide. Numerous studies have demonstrated that ferroptosis can participate in the biological malignant process of various tumor, including CRC, so understanding the role and regulatory mechanisms of ferroptosis in CRC plays a crucial role in the treatment of CRC. In this paper, we reviews the mechanisms of ferroptosis in CRC, the associated regulatory factors and their interactions with various immune cells in the immune microenvironment. In addition, targeting ferroptosis has emerged as an encouraging strategy for CRC treatment. Finally, to inform subsequent research and clinical diagnosis and treatment, we review therapeutic approaches to CRC radiotherapy, immunotherapy, and herbal therapy targeting ferroptosis.
铁死亡是一种不同于传统死亡形式的新型细胞死亡方式。它是依赖于铁死亡的脂质过氧化死亡。结直肠癌（CRC）是胃肠道最常见的肿瘤，具有较长的隐匿期和较差的五年预后。探索有效的结直肠癌系统治疗方法仍然是全世界面临的巨大挑战。大量研究表明，铁死亡可以参与包括 CRC 在内的各种肿瘤的生物学恶性过程，因此了解铁死亡在 CRC 中的作用和调节机制对于 CRC 的治疗至关重要。在本文中，我们综述了结直肠癌中铁死亡的机制、相关调节因子及其与免疫微环境中各种免疫细胞的相互作用。此外，靶向铁死亡已成为 CRC 治疗的一种有前途的策略。最后，为了为后续的研究和临床诊断和治疗提供信息，我们综述了针对铁死亡的 CRC 放疗、免疫疗法和草药疗法的治疗方法。
