Tu Hua, Han Hui, Zhou Fang-Jian, Li Yong-Hong, Qin Zi-Ke, Liu Zhuo-Wei
Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060,P.R. China.
Ai Zheng. 2009 Aug;28(8):879-81. doi: 10.5732/cjc.008.10792.
Extramammary Paget's disease (EMPD) of the scrotum with sweat gland adenocarcinoma is a rare malignant tumor. This study was to summarize the clinicopathologic characteristics of scrotum Paget's disease with underlying sweat gland adenocarcinoma, and analyze the treatment outcome.
Clinical data of six scrotum Paget's disease patients with sweat gland adenocarcinoma, treated in Sun Yat-sen University Cancer Center from 1964 to 2004, were analyzed with literature review.
The typical manifestation of scrotum Paget's disease with sweat gland adenocarcinoma was eczematoid-like skin changes. All patients underwent primary lesion resection plus uni-inguinal lymphadenectomy, one patient underwent rectus abdominis pedicle flap transplantation. Three patients died of tumor at 15, 26, 38 months after operation, respectively. Other three patients were followed up for 48, 50, 55 months, respectively, and were alive without tumor.
The primary lesion resection plus uni-inguinal lymphadenectomy is the major treatment for scrotum Paget's disease with underlying sweat gland adenocarcinoma.
阴囊外佩吉特病（EMPD）合并汗腺腺癌是一种罕见的恶性肿瘤。本研究旨在总结阴囊佩吉特病合并潜在汗腺腺癌的临床病理特征，并分析其治疗结果。
对1964年至2004年在中山大学肿瘤防治中心治疗的6例阴囊佩吉特病合并汗腺腺癌患者的临床资料进行分析，并复习相关文献。
阴囊佩吉特病合并汗腺腺癌的典型表现为湿疹样皮肤改变。所有患者均接受了原发灶切除加单侧腹股沟淋巴结清扫术，1例患者接受了腹直肌蒂皮瓣移植术。3例患者分别于术后15、26、38个月死于肿瘤。另外3例患者分别随访48、50、55个月，均存活且无肿瘤复发。
原发灶切除加单侧腹股沟淋巴结清扫术是阴囊佩吉特病合并潜在汗腺腺癌的主要治疗方法。
