Calpe-Berdiel Laura, Méndez-González Jesús, Blanco-Vaca Francisco, Carles Escolà-Gil Joan
Hospital de la Santa Creu i Sant Pau, Servei de Bioquímica, Barcelona, Spain.
Curr Atheroscler Rep. 2009 Sep;11(5):391-8. doi: 10.1007/s11883-009-0059-x.
A number of studies have raised the possibility of circulating plant sterols being a risk factor in the pathogenesis of atherosclerosis. Evidence in support of this hypothesis comes mainly from observations in sitosterolemic patients, who hyperabsorb plant sterols and suffer premature atherosclerosis. Accordingly, the atherogenicity of plant sterols of dietary origin is currently under debate, in view of the widespread use of cholesterol-lowering functional foods enriched with these compounds. Although some reports have suggested the vascular perils of small increases in plasma plant sterol concentrations, other prospective and large population-based studies have indicated otherwise. Further, the potential risk of plant sterol-enriched foods may be counterbalanced by the notable reduction in plasma cholesterol. This review summarizes the current evidence on the possible impact of plant sterols as a risk factor for atherosclerosis.
多项研究提出，循环植物甾醇可能是动脉粥样硬化发病机制中的一个危险因素。支持这一假说的证据主要来自对谷甾醇血症患者的观察，这些患者会过度吸收植物甾醇并罹患早发性动脉粥样硬化。因此，鉴于富含这些化合物的降胆固醇功能食品的广泛使用，膳食来源的植物甾醇的致动脉粥样硬化性目前仍存在争议。尽管一些报告表明血浆植物甾醇浓度小幅升高存在血管风险，但其他前瞻性和基于大量人群的研究则得出了相反的结论。此外，富含植物甾醇的食品的潜在风险可能会被血浆胆固醇的显著降低所抵消。本综述总结了关于植物甾醇作为动脉粥样硬化危险因素可能产生的影响的现有证据。
