Reichardt Peter, Hogendoorn Pancras C W, Tamborini Elena, Loda Massimo, Gronchi Alessandro, Poveda Andrés, Schöffski Patrick
Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany.
Semin Oncol. 2009 Aug;36(4):290-301. doi: 10.1053/j.seminoncol.2009.06.002.
Gastrointestinal stromal tumor (GISTs) are the most common connective tissue malignancies of the gastrointestinal (GI) tract, with an incidence on the order of 10-13 per million people per year. Primary therapy is usually surgical, but the recurrence rate of large, so-called high-risk tumors, with a high mitotic rate, or those arising from small bowel and colon/rectum is particularly high. The natural history, pathology, and molecular biology of GISTs are discussed in this review, as are features of increasing our analytical power of the genes altered in these tumors, surgical issues, and the translation of research findings into clinical practice. The biological features of GIST make it a model for the examination of kinase-targeted therapeutics in solid tumors.
胃肠道间质瘤（GISTs）是胃肠道最常见的结缔组织恶性肿瘤，每年发病率约为百万分之10 - 13。主要治疗方法通常是手术，但大的、所谓高危肿瘤（有高有丝分裂率，或起源于小肠和结肠/直肠的肿瘤）的复发率特别高。本综述讨论了GISTs的自然病史、病理学和分子生物学，以及提高我们对这些肿瘤中改变基因的分析能力的特征、手术问题，以及将研究结果转化为临床实践。GISTs的生物学特性使其成为实体瘤中激酶靶向治疗研究的典范。
