细胞周期和Myc与调节多能性和重编程的机制相互交织。
The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming.
作者信息
Singh Amar M, Dalton Stephen
机构信息
Department of Biochemistry and Molecular Biology, Paul D. Coverdell Center for Biomedical and Health Sciences, The University of Georgia, Athens, GA 30602, USA.
出版信息
Cell Stem Cell. 2009 Aug 7;5(2):141-9. doi: 10.1016/j.stem.2009.07.003.
Abstract
Pluripotent stem cells have long-term proliferative capacity and an unusual mode of cell-cycle regulation and can divide independently of extrinsic mitogenic signals. The last few years has seen evidence emerge that links cell-cycle regulation to the maintenance and establishment of pluripotency. Myc transcription factors appear to be central to this regulation. This review addresses these links and discusses how cell-cycle controls and Myc impact on the maintenance and establishment of pluripotency.
摘要
多能干细胞具有长期增殖能力和独特的细胞周期调控模式，能够独立于外在促有丝分裂信号进行分裂。在过去几年中，有证据表明细胞周期调控与多能性的维持和建立有关。Myc转录因子似乎在这种调控中起着核心作用。本综述阐述了这些联系，并讨论了细胞周期控制和Myc如何影响多能性的维持和建立。
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