基于 N-杂环壳聚糖衍生物的凝胶的制备及性能研究及其在生物医学中的应用。
Preparation and characterization of N-heterocyclic chitosan derivative based gels for biomedical applications.
机构信息
Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad 21100, India.
出版信息
Int J Biol Macromol. 2009 Nov 1;45(4):330-7. doi: 10.1016/j.ijbiomac.2009.08.002. Epub 2009 Aug 7.
The novel N-heterocyclic chitosan aerogel derivatives were prepared by reacting 79% deacetylated chitosan separately with 4-pyridinecarboxaldehyde and 2,6-pyridinedicarboxaldehyde followed by subsequent solvent exchange into acetone, filteration and lyophilization. The identity of the Schiff bases was confirmed by UV-vis absorption spectroscopy and Fourier transform infrared (FTIR) spectroscopy. The N-heterocyclic chitosan derivatives were evaluated by X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), rheological studies and biological activity. Overall, the N-heterocyclic chitosan derivative based gels open new perspectives in biomedical applications.
新型 N-杂环壳聚糖气凝胶衍生物是通过分别用 4-吡啶甲醛和 2,6-吡啶二甲酸醛与 79%脱乙酰壳聚糖反应，然后将溶剂交换为丙酮，过滤和冻干而制备的。席夫碱的结构通过紫外可见吸收光谱和傅里叶变换红外（FTIR）光谱得到证实。通过 X 射线衍射（XRD）、热重分析（TGA）、差示扫描量热法（DSC）、扫描电子显微镜（SEM）、流变学研究和生物活性对 N-杂环壳聚糖衍生物进行了评估。总的来说，基于 N-杂环壳聚糖的衍生物凝胶为生物医学应用开辟了新的前景。
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