Department of Textile Engineering, Konkuk University, Seoul 143701, South Korea.
Int J Biol Macromol. 2011 Oct 1;49(3):356-61. doi: 10.1016/j.ijbiomac.2011.05.017. Epub 2011 May 26.
This paper describes an elegant cross-linking technique for the preparation of chitosan-chloroquinoline derivative by using a greener technique. Chitosan solution in aqueous acetic acid was treated with 2-chloroquinoline-3-carbaldehyde solution to form hydrogel; the resulting hydrogel was subjected to solvent exchange. Combining the results of FTIR and XRD confirmed that 2-chloroquinoline-3-carbaldehyde have been reacted to chitosan. The morphology of the derivative was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The thermal stability of the derivative was examined by thermogravimetric analysis (TGA). The photoluminescence (PL) spectra of chitosan-chloroquinoline derivative show red-shifted emission maximum. The microbiological screening has demonstrated the antimicrobial activity of the derivative against bacteria viz. Staphylococcus aureus, Escherichia coli and Candida albicans. The obtained results showed that the chitosan-chloroquinoline derivative might be a promising candidate for novel antimicrobial agents for biomedical applications.
本文描述了一种通过更绿色的技术制备壳聚糖-氯喹啉衍生物的优雅交联技术。将壳聚糖在醋酸水溶液中与 2-氯喹啉-3-甲醛溶液处理，形成水凝胶；所得水凝胶进行溶剂交换。FTIR 和 XRD 的结果结合证实 2-氯喹啉-3-甲醛已与壳聚糖反应。通过 X 射线衍射（XRD）和扫描电子显微镜（SEM）研究了衍生物的形态。通过热重分析（TGA）研究了衍生物的热稳定性。壳聚糖-氯喹啉衍生物的光致发光（PL）光谱显示出发射最大值的红移。微生物筛选表明，该衍生物对金黄色葡萄球菌、大肠杆菌和白色念珠菌等细菌具有抗菌活性。所得结果表明，壳聚糖-氯喹啉衍生物可能是一种有前途的候选新型抗菌药物，可用于生物医学应用。
