Yadav Neena, Francis Arul Prakash, Priya Veeraraghavan Vishnu, Patil Shankargouda, Mustaq Shazia, Khan Sameer Saeed, Alzahrani Khalid J, Banjer Hamsa Jameel, Mohan Surapaneni Krishna, Mony Ullas, Rajagopalan Rukkumani
Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Institute of Medical & Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai 600077, India.
Polymers (Basel). 2022 Feb 27;14(5):950. doi: 10.3390/polym14050950.
Cancer is one of the most widespread deadly diseases, following cardiovascular disease, worldwide. Chemotherapy is widely used in combination with surgery, hormone and radiation therapy to treat various cancers. However, chemotherapeutic drugs can cause severe side effects due to non-specific targeting, poor bioavailability, low therapeutic indices, and high dose requirements. Several drug carriers successfully overcome these issues and deliver drugs to the desired sites, reducing the side effects. Among various drug delivery systems, polysaccharide-based carriers that target only the cancer cells have been developed to overcome the toxicity of chemotherapeutics. Polysaccharides are non-toxic, biodegradable, hydrophilic biopolymers that can be easily modified chemically to improve the bioavailability and stability for delivering therapeutics into cancer tissues. Different polysaccharides, such as chitosan, alginates, cyclodextrin, pullulan, hyaluronic acid, dextran, guar gum, pectin, and cellulose, have been used in anti-cancer drug delivery systems. This review highlights the recent progress made in polysaccharides-based drug carriers in anti-cancer therapy.
癌症是全球范围内仅次于心血管疾病的最广泛传播的致命疾病之一。化疗广泛用于与手术、激素和放射治疗联合治疗各种癌症。然而，由于非特异性靶向、生物利用度差、治疗指数低和剂量要求高，化疗药物会引起严重的副作用。几种药物载体成功克服了这些问题，并将药物输送到所需部位，减少了副作用。在各种药物递送系统中，已开发出仅靶向癌细胞的基于多糖的载体，以克服化疗药物的毒性。多糖是无毒、可生物降解的亲水性生物聚合物，可通过化学方法轻松修饰，以提高将治疗剂递送至癌组织中的生物利用度和稳定性。不同的多糖，如壳聚糖、藻酸盐、环糊精、支链淀粉、透明质酸、葡聚糖、瓜尔胶、果胶和纤维素，已用于抗癌药物递送系统。本综述重点介绍了基于多糖的药物载体在抗癌治疗方面的最新进展。
