Dirix V, Verscheure V, Goetghebuer T, Hainaut M, Debrie A S, Locht C, Mascart F
Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), 808 route de Lennik, 1070 Brussels, Belgium.
Vaccine. 2009 Oct 9;27(43):6042-7. doi: 10.1016/j.vaccine.2009.07.075. Epub 2009 Aug 7.
Two different types of pertussis vaccines are currently available to protect children against whooping cough, the first-generation whole-cell (Pw) vaccines and the more recent acellular (Pa) vaccines. Both types provide good protection, yet induce different types of immune responses in 6-month-old infants, with a strong Th1 response induced by Pw vaccines compared to a mixed Th1/Th2 response and a delay in non-specific IFN-gamma secretions after the administration of Pa vaccines. We show here that at 13 months of age, most Pw- or Pa-vaccinated children display Bordetella pertussis-specific T-cell responses, in addition to significant antibody levels, although a higher Th2/Th1 cytokine ratio remained in Pa recipients compared to Pw recipients. In contrast, the proportion of children with tetanus toxin-specific T-cell responses was lower in Pa than in Pw vaccine recipients, although most children had protective anti-tetanus toxin IgG levels. In addition, the global Th2 bias observed in 6-month-old infants vaccinated with a Pa vaccine was normalized at 13 months.
目前有两种不同类型的百日咳疫苗可用于保护儿童预防百日咳，即第一代全细胞（Pw）疫苗和更新的无细胞（Pa）疫苗。两种类型的疫苗都能提供良好的保护，但在6个月大的婴儿中会引发不同类型的免疫反应，与Pa疫苗接种后诱导的混合Th1/Th2反应以及非特异性干扰素-γ分泌延迟相比，Pw疫苗会诱导强烈的Th1反应。我们在此表明，在13个月大时，大多数接种Pw或Pa疫苗的儿童除了具有显著的抗体水平外，还表现出百日咳博德特氏菌特异性T细胞反应，尽管与接种Pw疫苗的儿童相比，接种Pa疫苗的儿童中Th2/Th1细胞因子比率仍然较高。相比之下，接种Pa疫苗的儿童中破伤风毒素特异性T细胞反应的比例低于接种Pw疫苗的儿童，尽管大多数儿童具有保护性抗破伤风毒素IgG水平。此外，在接种Pa疫苗的6个月大婴儿中观察到的整体Th2偏向在13个月时恢复正常。
