抗凝监测。

Anticoagulation monitoring.

作者信息

Ng Valerie L

机构信息

Department of Pathology and Laboratory Medicine, Clinical Laboratory Room 3408, Alameda County Medical Center/Highland General Hospital, 1411 East 31st Street, Oakland, CA 94602, USA.

出版信息

Clin Lab Med. 2009 Jun;29(2):283-304. doi: 10.1016/j.cll.2009.05.003.

DOI:10.1016/j.cll.2009.05.003

PMID:19665679

Abstract

This article reviews the commonly used anticoagulants (warfarin and heparin) and associated recommended laboratory testing. Emphasis is on the various modes of International Normalized Ratio testing and associated variability (clinical laboratory, point of care, patient self-testing). Unfractionated heparin and well-recognized coagulation testing issues are reviewed. The newer anticoagulants (heparin analogs, direct factor Xa inhibitors, and direct thrombin inhibitors) and various applied coagulation laboratory testing and related issues are also discussed.

摘要

本文回顾了常用的抗凝剂（华法林和肝素）以及相关的推荐实验室检测。重点在于国际标准化比值检测的各种模式及其相关变异性（临床实验室检测、即时检测、患者自我检测）。还回顾了普通肝素以及公认的凝血检测问题。此外，也讨论了新型抗凝剂（肝素类似物、直接Xa因子抑制剂和直接凝血酶抑制剂）以及各种应用的凝血实验室检测和相关问题。