London Erwin, Shahidullah Khurshida
Department of Biochemistry and Cell Biology, Stony Brook, NY 11794-5215, USA.
Curr Opin Struct Biol. 2009 Aug;19(4):464-72. doi: 10.1016/j.sbi.2009.07.007. Epub 2009 Aug 7.
Experimental studies have begun to define how formation of transmembrane (TM) vs. non-TM hydrophobic helix topographies is controlled. It has been found that topography is very sensitive to sequence and lipid structure. Interestingly, there is a broad agreement between studies using artificial model membranes and natural membranes. These studies provide important insights into membrane protein insertion and function.
实验研究已开始明确跨膜（TM）与非跨膜疏水螺旋拓扑结构的形成是如何被控制的。研究发现，拓扑结构对序列和脂质结构非常敏感。有趣的是，使用人工模型膜和天然膜的研究之间存在广泛共识。这些研究为膜蛋白插入和功能提供了重要见解。
