Koreishi Aashiyana F, Saenz Adam J, Fleming Stephen E, Teruya-Feldstein Julie
Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, USA.
Int J Surg Pathol. 2009 Oct;17(5):384-9. doi: 10.1177/1066896909342568. Epub 2009 Aug 10.
The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.
作者描述了在纪念斯隆-凯特琳癌症中心1年时间内（2008年7月至2009年6月）诊断出的3例脾脏硬化性血管瘤样结节性转化（SANT）病例。所有患者均为女性，年龄超过50岁，病变大小在2至4厘米之间。脾切除术后所有患者均存活且情况良好。所有病例均显示出文献中先前描述的特征性组织学和免疫表型表现，包括在纤维硬化基质中有散在的IgG4阳性浆细胞。3例患者中有2例有癌症病史，存在转移的担忧，但其中1例患者的PET扫描显示FDG活性极低或无活性，提示该病变为良性惰性病变。然而，1例患者的PET扫描显示FDG活性阳性，增加了对恶性肿瘤的临床担忧。
