Noble M I, Drake-Holland A J
Academic Unit of Cardiovascular Medicine, Charing Cross and Westminster Medical School, London, UK.
Clin Physiol Biochem. 1990;8 Suppl 3:50-5.
We report recently published results in dogs by Torr et al. in which the accumulation of platelet thrombi in canine coronary arteries was abolished by the specific serotonin 5HT2 receptor antagonist, ritanserin. The serotonin blockade by ritanserin also prevented the re-establishment of thrombi by adrenaline infusion. 61 humans with critical coronary artery stenoses shown by coronary angiography were divided into control and serotonin antagonist (31 ketanserin administration) groups. While awaiting coronary artery bypass grafting or angioplasty, 7 of the subjects in the control group had coronary arterial occlusions, 4 of whom died. The only occlusion in the serotonin antagonism group occurred in a subject who died suddenly after 2 years of study. The probability of the occlusion rate in subjects subjected to serotonin antagonism being the same as that of the control subjects was less than 0.0245, by Fisher's exact test. It is concluded that serotonin may be as important in mediating coronary thrombosis in man as it is in animals.
我们报告了托尔等人最近在犬类身上发表的研究结果，其中特异性5-羟色胺5HT2受体拮抗剂利坦色林消除了犬冠状动脉中血小板血栓的形成。利坦色林对5-羟色胺的阻断作用还通过肾上腺素输注阻止了血栓的重新形成。61例经冠状动脉造影显示存在严重冠状动脉狭窄的患者被分为对照组和5-羟色胺拮抗剂（31例给予酮色林）组。在等待冠状动脉搭桥术或血管成形术期间，对照组中有7名受试者发生冠状动脉闭塞，其中4人死亡。5-羟色胺拮抗组中唯一的闭塞发生在一名研究2年后突然死亡的受试者身上。通过费舍尔精确检验，5-羟色胺拮抗组受试者的闭塞率与对照组相同的概率小于0.0245。得出的结论是，5-羟色胺在介导人类冠状动脉血栓形成中可能与在动物中一样重要。
