多发性硬化症的神经眼科方面：将眼球运动用作临床和实验工具。
Neuro-ophthalmologic aspects of multiple sclerosis: Using eye movements as a clinical and experimental tool.
作者信息
Niestroy Annette, Rucker Janet C, Leigh R John
机构信息
Neurology Service, Louis Stokes Department of Veterans Affairs Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
出版信息
Clin Ophthalmol. 2007 Sep;1(3):267-72.
Ocular motor disorders are a well recognized feature of multiple sclerosis (MS). Clinical abnormalities of eye movements, early in the disease course, are associated with generalized disability, probably because the burden of disease in affected patients falls on the brainstem and cerebellar pathways, which are important for gait and balance. Measurement of eye movements, especially when used to detect internuclear ophthalmoplegia (INO), may aid diagnosis of MS. Measurement of the ocular following response to moving sinusoidal gratings of specified spatial frequency and contrast can be used as an experimental tool to better understand persistent visual complaints in patients who have suffered optic neuritis. Patients with MS who develop acquired pendular nystagmus often benefit from treatment with gabapentin or memantine.
眼球运动障碍是多发性硬化症（MS）的一个公认特征。在疾病进程早期出现的眼球运动临床异常与全身残疾相关，这可能是因为受影响患者的疾病负担落在对步态和平衡至关重要的脑干和小脑通路上。眼球运动的测量，尤其是用于检测核间性眼肌麻痹（INO）时，可能有助于MS的诊断。测量对特定空间频率和对比度的移动正弦光栅的眼球跟随反应可作为一种实验工具，以更好地理解视神经炎患者持续存在的视觉症状。发生后天性摆动性眼球震颤的MS患者通常受益于加巴喷丁或美金刚治疗。
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