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一名正在接受先天性甲状腺功能减退症治疗的儿科患者中疑似左甲状腺素诱发的假性脑瘤。

Presumed levothyroxine-induced pseudotumor cerebri in a pediatric patient being treated for congenital hypothyroidism.

作者信息

Strickler Crystal, Pilon Andrew F

机构信息

Illinois College of Optometry, Chicago, IL, USA.

出版信息

Clin Ophthalmol. 2007 Dec;1(4):545-9.

PMID:19668534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2704528/
Abstract

Papilledema is considered a neuro-ophthalmic emergency because of its capacity to induce irreversible end-organ damage and the often grave nature of its precipitating factor. Even more concern is warranted when papilledema presents in a pediatric setting. After excluded the contributions of intracranial masses, congenital malformations, ischemic insults and acute infections, the investigation must focus on determining the contributions of other uncharacteristic causes of pediatric pseudotumor cerebri. Pediatric pseudotumor cerebri is a rare clinical entity which shares few commonalities to the adult condition in regards to its predicating factors or symptoms. Without adequate medical history questioning, funduscopic evaluation and ancillary testing, the possibility of an erroneous diagnosis is plausible. This case report aims to disclose the toxic role levothyroxine sodium tablets (Synthroid((R)), Abbott Laboratories, Abbott Park, IL, USA) played in inducing pseudotumor cerebri in a pediatric patient being treated for congenital hypothyroidism.

摘要

视乳头水肿被视为一种神经眼科急症,因为它有能力导致不可逆的终末器官损害,且其诱发因素往往性质严重。当视乳头水肿出现在儿科患者中时,更应引起关注。在排除颅内肿块、先天性畸形、缺血性损伤和急性感染的因素后,调查必须集中于确定其他导致儿童假性脑瘤的非典型病因。儿童假性脑瘤是一种罕见的临床病症,在其诱发因素或症状方面与成人病症几乎没有共同之处。如果没有进行充分的病史询问、眼底镜检查和辅助检查,就有可能做出错误诊断。本病例报告旨在揭示左甲状腺素钠片(优甲乐(R),美国雅培公司,伊利诺伊州雅培公园)在一名接受先天性甲状腺功能减退治疗的儿科患者中诱发假性脑瘤所起的毒性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/486a/2704528/6c3d765725a1/opth-1-545f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/486a/2704528/6c3d765725a1/opth-1-545f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/486a/2704528/6c3d765725a1/opth-1-545f1.jpg

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本文引用的文献

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Pediatric optic nerve sheath decompression.小儿视神经鞘减压术
Ophthalmology. 2005 Apr;112(4):724-7. doi: 10.1016/j.ophtha.2004.11.049.
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Idiopathic intracranial hypertension after L-thyroxine therapy for acquired primary hypothyroidism.左旋甲状腺素治疗获得性原发性甲状腺功能减退症后发生的特发性颅内高压。
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Pseudotumor cerebri associated with initiation of levothyroxine therapy for juvenile hypothyroidism.与青少年甲状腺功能减退症左甲状腺素治疗起始相关的假性脑瘤
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