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高眼压症和早期青光眼患者获得性色觉及视野缺损

Acquired color vision and visual field defects in patients with ocular hypertension and early glaucoma.

作者信息

Papaconstantinou Dimitris, Georgalas Ilias, Kalantzis George, Karmiris Efthimios, Koutsandrea Chrysanthi, Diagourtas Andreas, Ladas Ioannis, Georgopoulos Gerasimos

机构信息

Department of Ophthalmology, University of Athens, Athens, Greece.

出版信息

Clin Ophthalmol. 2009;3:251-7. Epub 2009 Jun 2.

PMID:19668575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2709000/
Abstract

PURPOSE

To study acquired color vision and visual field defects in patients with ocular hypertension (OH) and early glaucoma.

METHODS

In a prospective study we evaluated 99 eyes of 56 patients with OH without visual field defects and no hereditary color deficiencies, followed up for 4 to 6 years (mean = 4.7 +/- 0.6 years). Color vision defects were studied using a special computer program for Farnsworth-Munsell 100 hue test and visual field tests were performed with Humphrey analyzer using program 30-2. Both tests were repeated every six months.

RESULTS

In fifty-six eyes, glaucomatous defects were observed during the follow-up period. There was a statistically significant difference in total error score (TES) between eyes that eventually developed glaucoma (157.89 +/- 31.79) and OH eyes (75.51 +/- 31.57) at the first examination (t value 12.816, p < 0.001). At the same time visual field indices were within normal limits in both groups. In the glaucomatous eyes the earliest statistical significant change in TES was identified at the first year of follow-up and was -20.62 +/- 2.75 (t value 9.08, p < 0.001) while in OH eyes was -2.11 +/- 4.36 (t value 1.1, p = 0.276). Pearson's coefficient was high in all examinations and showed a direct correlation between TES and mean deviation and corrected pattern standard deviation in both groups.

CONCLUSION

Quantitative analysis of color vision defects provides the possibility of follow-up and can prove a useful means for detecting early glaucomatous changes in patients with normal visual fields.

摘要

目的

研究高眼压症（OH）和早期青光眼患者获得性色觉及视野缺损情况。

方法

在一项前瞻性研究中，我们评估了56例无视野缺损且无遗传性色觉缺陷的高眼压症患者的99只眼，随访4至6年（平均 = 4.7 +/- 0.6年）。使用用于Farnsworth-Munsell 100色调测试的特殊计算机程序研究色觉缺陷，并用Humphrey分析仪使用程序30-2进行视野测试。两项测试均每六个月重复一次。

结果

在随访期间，56只眼中观察到青光眼性缺损。最终发生青光眼的眼（157.89 +/- 31.79）与首次检查时的高眼压症眼（75.51 +/- 31.57）之间的总误差评分（TES）存在统计学显著差异（t值12.816，p < 0.001）。同时，两组的视野指数均在正常范围内。在青光眼眼中，TES最早的统计学显著变化在随访的第一年被确定，为-20.62 +/- 2.75（t值9.08，p < 0.001），而在高眼压症眼中为-2.11 +/- 4.36（t值1.1，p = 0.276）。在所有检查中，皮尔逊系数都很高，并且显示两组中TES与平均偏差和校正模式标准偏差之间存在直接相关性。

结论

色觉缺陷的定量分析提供了随访的可能性，并且可以证明是检测视野正常患者早期青光眼性变化的有用手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5150/2709000/8bf03746a278/opth-3-251f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5150/2709000/0bd554fcf699/opth-3-251f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5150/2709000/8bf03746a278/opth-3-251f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5150/2709000/0bd554fcf699/opth-3-251f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5150/2709000/8bf03746a278/opth-3-251f2.jpg

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