Georgopoulos G, Andreanos D, Liokis N, Papakonstantinou D, Vergados J, Theodossiadis G
Department of Glaucoma, University Eye Clinic of Athens, Greece.
Eur J Ophthalmol. 1997 Oct-Dec;7(4):357-63. doi: 10.1177/112067219700700409.
The aim of the study was to determine whether certain factors are related to an increased risk of developing open-angle glaucoma. A total of 345 untreated glaucoma suspects with intraocular pressure (IOP) > or = 21 mmHg, cup to disc ratio 0.4 or less and no visual field defects, were followed up for 6 to 8 years (mean 7.3). During the follow-up 71 patients developed established glaucoma and were compared to the remaining 274 patients. The following factors were analysed: age, family history of glaucoma, IOP, Humphrey 30-2 visual fields, optic disc appearance, myopia, exfoliation, arterial hypertension and diabetes. Analysis yielded statistically significant results regarding a number of these factors in the patients who subsequently developed open-angle glaucoma. A significant association with the subsequent development of field loss in ocular hypertension (OHT) included: heredity (p < 0.001), age > or = 60 years (p = 0.013), axial myopia (0.001 < p < 0.01) and arterial hypertension (p = 0.05). About 20% of patients with ocular hypertension developed glaucoma over a period of seven years. Risk factors such as heredity, age, myopia and arterial hypertension, among others, must be considered in the follow-up of glaucoma suspects.
该研究的目的是确定某些因素是否与开角型青光眼发病风险增加相关。共有345名未经治疗的青光眼疑似患者，其眼压（IOP）≥21 mmHg，杯盘比为0.4或更小且无视野缺损，随访6至8年（平均7.3年）。随访期间，71名患者发展为确诊青光眼，并与其余274名患者进行比较。分析了以下因素：年龄、青光眼家族史、眼压、Humphrey 30 - 2视野、视盘外观、近视、剥脱、动脉高血压和糖尿病。对于随后发生开角型青光眼的患者，对其中一些因素的分析得出了具有统计学意义的结果。与高眼压症（OHT）患者随后发生视野缺损显著相关的因素包括：遗传（p < 0.001）、年龄≥60岁（p = 0.013）、轴性近视（0.001 < p < 0.01）和动脉高血压（p = 0.05）。约20%的高眼压症患者在7年时间里发展为青光眼。在青光眼疑似患者的随访中，必须考虑遗传、年龄、近视和动脉高血压等危险因素。
