Kanavaros P, Hoang C, Le Bodic M F, Polivka M, Hautefeuille P
Department of Pathology, Lariboisière Hospital, Paris, France.
Histol Histopathol. 1990 Jul;5(3):325-8.
Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, argyrophilic non-argentaffin pancreatic endocrine tumours with tumour cells containing round neurosecretory granules are exceptional. In this study we describe such a tumour not associated with clinical evidence of carcinoid syndrome in a 60-year-old woman. Histological examination revealed tumour extension in pancreatic lymphatic vessels and veins but no evidence of locoregional or distant metastases. Ten months after surgery the patient showed no recurrence of the disease. Immunohistochemistry revealed cytoplasmic serotonin production in the tumour cells which were negative for anti-gastrin, insulin, glucagon, somatostatin, pancreatic polypeptide (PP), vasoactive intestinal peptide (VIP) and ACTH. This study emphasizes the usefulness of combined ultrastructural and immunohistochemical investigations in order to identify and characterize the rare pancreatic endocrine tumours with serotonin production.
产生血清素的胰腺内分泌肿瘤是罕见的肿瘤，在大多数情况下表现出恶性生物学行为。在大多数有充分记录的病例中，这些肿瘤由嗜银和亲银阳性细胞组成，这些细胞含有大量多形性神经分泌颗粒。相比之下，肿瘤细胞含有圆形神经分泌颗粒的嗜银非亲银胰腺内分泌肿瘤则较为罕见。在本研究中，我们描述了一名60岁女性的此类肿瘤，该肿瘤无类癌综合征的临床证据。组织学检查显示肿瘤在胰腺淋巴管和静脉中扩展，但无局部或远处转移的证据。手术后十个月，患者未出现疾病复发。免疫组织化学显示肿瘤细胞胞质产生血清素，这些细胞对抗胃泌素、胰岛素、胰高血糖素、生长抑素、胰多肽（PP）、血管活性肠肽（VIP）和促肾上腺皮质激素（ACTH）呈阴性。本研究强调了联合超微结构和免疫组织化学研究在识别和表征罕见的产生血清素的胰腺内分泌肿瘤方面的有用性。
