Landini G, Kitano M, Urago A
Facultad de Odontología, Montevideo, Uruguay.
An Fac Odontol. 1990 Dec(26):49-61.
The metastasizing pleomorphic adenoma of the salivary glands is a rare variant of pleomorphic adenoma with a benign microscopical appearance, but malignant biological behaviour and production of metastasis. The histopathological study with the routine techniques is not enough for disclosing the nature of these tumors and they are most of the times underdiagnosed as benign. The correct diagnosis, almost always too late, is evident after several recurrences and the detection of metastatic foci. The number of nucleolar organizing regions (NORs) detected with the silver colloid method can be used in histopathology to determine the degree of cell activity. We report the findings in a case of metastasizing pleomorphic adenoma of the submandibular gland. This technique demonstrated to be useful for the diagnosis and characterization of the metabolism of these tumors.
涎腺转移性多形性腺瘤是多形性腺瘤的一种罕见变异型，其显微镜下表现为良性，但具有恶性生物学行为并可发生转移。采用常规技术进行组织病理学研究不足以揭示这些肿瘤的本质，大多数情况下它们被误诊为良性。正确诊断往往很晚才做出，通常是在多次复发并检测到转移灶之后才明确。用银胶体法检测核仁组织区（NORs）的数量可用于组织病理学中确定细胞活性程度。我们报告了1例下颌下腺转移性多形性腺瘤的研究结果。该技术被证明对这些肿瘤的诊断和代谢特征分析有用。
