Landini G
Department of Oral Pathology, Kagoshima University Dental School, Japan.
J Oral Pathol Med. 1990 Jul;19(6):257-60. doi: 10.1111/j.1600-0714.1990.tb00837.x.
The number of nucleolar organizing regions (NORs) can be used to reveal the degree of cell activity or metabolism in histopathology specimens. Forty-one cases of pleomorphic adenomas of the salivary glands were studied with a silver nitrate colloid staining method to demonstrate the NORs in the cells of the solid and duct pattern areas and in chondroid areas. Acinic and intercalated ducts cells of the surrounding normal salivary glands were also examined. The data was analyzed statistically and it was found that the cells in the solid/ductal areas had a higher cellular activity than the chondroid cells. This difference is probably directly related with the possibility of malignant transformation and the incidence of the different types of malignant pleomorphic adenomas. Furthermore, it is concluded that the number of NORs in pleomorphic adenomas to define malignancy should be done discriminating between the different histologic patterns because of their different metabolic activities.
核仁组织区（NORs）的数量可用于揭示组织病理学标本中的细胞活性或代谢程度。采用硝酸银胶体染色法对41例涎腺多形性腺瘤进行研究，以显示实性和导管样区域以及软骨样区域细胞中的NORs。还检查了周围正常涎腺的腺泡和闰管细胞。对数据进行统计学分析，发现实性/导管样区域的细胞比软骨样细胞具有更高的细胞活性。这种差异可能与恶性转化的可能性以及不同类型恶性多形性腺瘤的发生率直接相关。此外，得出结论，由于多形性腺瘤不同组织学模式的代谢活性不同，因此在定义恶性肿瘤时应区分不同组织学模式的NORs数量。
