Mendonça Ricardo José de, Coutinho-Netto Joaquim
Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
An Bras Dermatol. 2009 Jul;84(3):257-62. doi: 10.1590/s0365-05962009000300007.
Wound healing is a dynamic interactive process that involves a sequence of molecular and cellular events. Recent advances in cellular and molecular biology have greatly expanded our understanding of the biological process involved in wound repair and tissue regeneration. From plasma extravasation, with coagulation and platelet aggregation, to reepithelialization and remodeling of injured tissue, the organism acts by trying to restore functionality tissue. Thus, the present study encompasses several cellular aspects involved in the wound healing process, as well as the main drugs used in treating the pathology related to wound healing complications. Economic aspects are also addressed, mainly related to chronic wounds of diabetic feet.
伤口愈合是一个动态的相互作用过程，涉及一系列分子和细胞事件。细胞和分子生物学的最新进展极大地扩展了我们对伤口修复和组织再生所涉及的生物学过程的理解。从血浆外渗、凝血和血小板聚集，到上皮再形成和受损组织重塑，机体通过试图恢复组织功能来发挥作用。因此，本研究涵盖了伤口愈合过程中涉及的几个细胞方面，以及用于治疗与伤口愈合并发症相关病理的主要药物。还讨论了经济方面，主要涉及糖尿病足慢性伤口。
