Gonzalez Ana Cristina de Oliveira, Costa Tila Fortuna, Andrade Zilton de Araújo, Medrado Alena Ribeiro Alves Peixoto
Fundação Oswaldo Cruz (Fiocruz), Salvador, BA, Brazil.
Bahiana School of Medicine and Public Health (EBMSP), Salvador, BA, Brazil.
An Bras Dermatol. 2016 Sep-Oct;91(5):614-620. doi: 10.1590/abd1806-4841.20164741.
Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
再生和组织修复过程由一系列分子和细胞事件组成，这些事件在组织损伤发生后出现，以修复受损组织。渗出、增殖和细胞外基质重塑阶段是通过涉及可溶性介质、血细胞和实质细胞的动态过程整合而发生的连续事件。损伤后发生的渗出现象会导致组织水肿的发展。增殖阶段试图通过肌成纤维细胞收缩和纤维组织增生来减少组织损伤面积。在这个阶段，仍可观察到血管生成和上皮再形成过程。内皮细胞能够分化为间充质成分，这种分化似乎由文献中研究的一组信号蛋白精细调控。这条途径被称为刺猬信号通路。本综述的目的是描述皮肤愈合过程中涉及的各种细胞和分子方面。
