Wittkowski U, Spies C, Sander M, Erb J, Feldheiser A, von Heymann C
Universitätsklinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Virchow-Klinikum und Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin.
Anaesthesist. 2009 Aug;58(8):764-78, 780-6. doi: 10.1007/s00101-009-1590-4.
A regular hydration status and compensated vascular filling are targets of perioperative fluid and volume management and, in parallel, represent precautions for sufficient stroke volume and cardiac output to maintain tissue oxygenation. The physiological and pathophysiological effects of fluid and volume replacement mainly depend on the pharmacological properties of the solutions used, the magnitude of the applied volume as well as the timing of volume replacement during surgery. In the perioperative setting surgical stress induces physiological and hormonal adaptations of the body, which in conjunction with an increased permeability of the vascular endothelial layer influence fluid and volume management. The target of haemodynamic monitoring in the operation room is to collect data on haemodynamics and global oxygen transport, which enable the anaesthetist to estimate the volume status of the vascular system. Particularly in high risk patients this may improve fluid and volume therapy with respect to maintaining cardiac output. A goal-directed volume management aiming at preventing hypovolaemia may improve the outcome after surgery. The objective of this article is to review the monitoring devices that are currently used to assess haemodynamics and filling status in the perioperative setting. Methods and principles for measuring haemodynamic variables, the measured and calculated parameters as well as clinical benefits and shortcomings of each device are described. Furthermore, the results for monitoring devices from clinical studies of goal-directed fluid and volume therapy which have been published will be discussed.
维持正常的水合状态和代偿性血管充盈是围手术期液体和容量管理的目标,同时也是确保足够的每搏输出量和心输出量以维持组织氧合的预防措施。液体和容量补充的生理及病理生理效应主要取决于所用溶液的药理学特性、补液量的大小以及手术期间补液的时机。在围手术期,手术应激会引起机体的生理和激素适应性变化,这些变化与血管内皮层通透性增加共同影响液体和容量管理。手术室血流动力学监测的目标是收集有关血流动力学和整体氧输送的数据,使麻醉医生能够评估血管系统的容量状态。特别是在高危患者中,这可能会改善维持心输出量方面的液体和容量治疗。旨在预防低血容量的目标导向性容量管理可能会改善术后结局。本文的目的是综述目前用于评估围手术期血流动力学和充盈状态的监测设备。描述了测量血流动力学变量的方法和原理、测量和计算参数以及每种设备的临床益处和缺点。此外,还将讨论已发表的目标导向性液体和容量治疗临床研究中监测设备的结果。