Weinbroum Avi A, Biderman Philippe, Soffer Dror, Klausner Joseph M, Szold Oded
Department of Anesthesiology and Critical Care, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Israel.
J Clin Monit Comput. 2008 Oct;22(5):361-6. doi: 10.1007/s10877-008-9143-y. Epub 2008 Oct 23.
For many years thermodilution has been the gold standard for determining cardiac output in the critically ill patients. Less invasive methods have recently been introduced. This study aimed at evaluating the agreement between cardiac output (CO) measured by a new Fick method, using central venous saturation (Scvo(2)), and that measured by the classic thermodilution technique, in patients requiring emergent CO evaluation.
Prospective clinical study in a university-affiliated, tertiary hospital, at surgical and general intensive care units.
Fifteen mechanically ventilated patients arriving in the emergency department in hemodynamic shock, had immediately a pulmonary artery catheter introduced under fluoroscopy upon arrival into the ICU. Cardiac output (CO) was obtained in each patient via both thermodilution and the Fick method, using oxygen consumption, SpO(2) and Scvo(2).
COs ranged between 2 and 2.3 (in the Fick and thermodilution methods, respectively) and 19 or 19.5 l/min (respectively). Mean thermodilution-derived CO was 6.2 +/- 4.2 l/min whereas the Fick's was 7.0 +/- 4.3 l/min. There was statistical significant correlation between the two modalities of measurements, with an r (2) = 0.9 (P < 0.001).
The new method of Fick assessed emergent CO as reliably as the thermodilution, regardless of whether it was low or high. The use of Scvo(2) allows for prompt bedside calculation for most emergency patients.
多年来,热稀释法一直是危重症患者心输出量测定的金标准。最近引入了侵入性较小的方法。本研究旨在评估一种新的利用中心静脉血氧饱和度(Scvo₂)的菲克法测量的心输出量(CO)与经典热稀释技术测量的心输出量之间的一致性,研究对象为需要紧急评估心输出量的患者。
在一所大学附属的三级医院的外科和综合重症监护病房进行的前瞻性临床研究。
15例因血流动力学休克抵达急诊科的机械通气患者,进入重症监护病房后立即在荧光透视引导下插入肺动脉导管。通过热稀释法和菲克法,利用耗氧量、SpO₂和Scvo₂获取每位患者的心输出量。
心输出量范围在2至2.3(分别为菲克法和热稀释法)以及19或19.5升/分钟(分别对应)之间。热稀释法得出的平均心输出量为6.2±4.2升/分钟,而菲克法为7.0±4.3升/分钟。两种测量方式之间存在统计学显著相关性,r² = 0.9(P < 0.001)。
新的菲克法评估紧急情况下的心输出量与热稀释法一样可靠,无论心输出量是高还是低。使用Scvo₂能够为大多数急诊患者在床边迅速进行计算。